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Treatment of urokinase-related anaphylactoid reaction with intravenous famotidine.

作者信息

Vidovich R R, Heiselman D E, Hudock D

机构信息

Critical Care Medicine, Akron General Medical Center, OH 44307.

出版信息

Ann Pharmacother. 1992 Jun;26(6):782-3. doi: 10.1177/106002809202600608.

DOI:10.1177/106002809202600608
PMID:1611161
Abstract

OBJECTIVE

We describe our experience with an anaphylactoid reaction to urokinase and the treatment used. We also discuss the use of histamine H1- and H2-blockers in combination for the treatment of allergic anaphylactoid reactions.

DESIGN

Case report.

SETTING

Hospital.

PARTICIPANTS

Observation of a patient who had a pulmonary embolism.

INTERVENTION

During the use of urokinase, in treatment of a pulmonary embolism, the patient developed an anaphylactoid reaction that did not respond to diphenhydramine or hydrocortisone. Famotidine was administered.

RESULTS

Abatement of urticaria and normalization of vital signs were obtained soon after famotidine was given. Completion of thrombolysis took place.

CONCLUSIONS

Further investigation of the use of H1- and H2-blocking agents in the presence of anaphylactoid reactions to thrombolytic agents should be performed. Consideration of intravenous famotidine for the treatment of anaphylactoid-type reactions to urokinase is suggested.

摘要

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