Ribatti Domenico, Nico Beatrice, Spinazzi Raffaella, Vacca Angelo, Nussdorfer Gastone G
Department of Human Anatomy and Histology, Piazza Giulio Cesare, 11, Policlinico, I-70124 Bari, Italy.
Peptides. 2005 Sep;26(9):1670-5. doi: 10.1016/j.peptides.2005.02.017. Epub 2005 Mar 17.
Adrenomedullin (AM) is a 52 amino acid peptide originally isolated from human pheochromocytoma. It was initially demonstrated to have profound effects in vascular cell biology, since AM protects endothelial cells from apoptosis, promotes angiogenesis and affects vascular tone and permeability. This review article summarizes the literature data concerning the relationship between AM and angiogenesis and describes the relationship between vascular endothelial growth factor, hypoxia and AM and tumor angiogenesis. Finally, the role of AM as a potential target of antiangiogenic therapy is discussed.
肾上腺髓质素（AM）是一种最初从人嗜铬细胞瘤中分离出来的含52个氨基酸的肽。它最初被证明在血管细胞生物学中具有深远影响，因为AM可保护内皮细胞免于凋亡、促进血管生成并影响血管张力和通透性。这篇综述文章总结了有关AM与血管生成之间关系的文献数据，并描述了血管内皮生长因子、缺氧与AM和肿瘤血管生成之间的关系。最后，讨论了AM作为抗血管生成治疗潜在靶点的作用。
