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维生素E对大鼠记忆保持的影响：胆碱能系统可能参与其中。

Effect of vitamin E on memory retention in rats: possible involvement of cholinergic system.

作者信息

Eidi Akram, Eidi Maryam, Mahmoodi Gelavij, Oryan Shahrbanoo

机构信息

Department of Biology, Science and Research Institute, Islamic Azad University, Tehran, Iran.

出版信息

Eur Neuropsychopharmacol. 2006 Feb;16(2):101-6. doi: 10.1016/j.euroneuro.2005.06.006. Epub 2005 Aug 19.

DOI:10.1016/j.euroneuro.2005.06.006
PMID:16112558
Abstract

This study concerned effects of vitamin E and the cholinergic system on memory retention of passive avoidance learning in rats. Post-training intracerebroventricular (i.c.v.) injections were carried out in all experiments. Administrations of vitamin E (10, 25 and 50 microg/rat), nicotine (0.1 microg/rat) and pilocarpine (0.5 microg/rat), the muscarinic receptor agonist increased memory retention, while mecamylamine (0.01, 0.1 and 0.5 microg/rat), the nicotinic receptor antagonist and scopolamine (0.1, 1 and 5 microg/rat), the muscarinic receptor antagonist decreased memory retention. The combination of vitamin E with nicotine or pilocarpine showed potentiation. Effects of mecamylamine or scopolamine were attenuated by vitamin E. It is concluded that vitamin E has a close interaction with cholinergic system in memory retention process.

摘要

本研究关注维生素E和胆碱能系统对大鼠被动回避学习记忆保持的影响。在所有实验中均进行了训练后脑室内注射。维生素E（10、25和50微克/只大鼠）、尼古丁（0.1微克/只大鼠）和毛果芸香碱（0.5微克/只大鼠，毒蕈碱受体激动剂）的给药增加了记忆保持，而尼古丁受体拮抗剂美加明（0.01、0.1和0.5微克/只大鼠）和毒蕈碱受体拮抗剂东莨菪碱（0.1、1和5微克/只大鼠）则降低了记忆保持。维生素E与尼古丁或毛果芸香碱联合使用显示出增强作用。维生素E减弱了美加明或东莨菪碱的作用。得出的结论是，在记忆保持过程中，维生素E与胆碱能系统存在密切的相互作用。

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