Corripio Iluminada, Pérez Víctor, Catafau Ana M, Mena Esther, Carrió Ignasi, Alvarez Enric
Department of Psychiatry, Hospital de la Sta Creu I Sant PauC, Universidad Autónoma de Barcelona (UAB) [corrected] Sant Antoni Maria Claret, 16708025 Barcelona, Spain.
Neuroimage. 2006 Jan 15;29(2):662-6. doi: 10.1016/j.neuroimage.2005.07.038. Epub 2005 Aug 19.
In a preliminary 123I-IBZM SPECT study in first-episode psychosis, a relationship between striatal dopaminergic D2 receptor (D2R) binding and premorbid adjustment was suggested. These results were replicated in the present study (n = 18), and D2R binding at diagnosis predicted a high probability for schizophrenia outcome by 2-year follow-up. The present findings contribute to the evidence of abnormal D2R binding in schizophrenia and suggest that SPECT might be useful for outcome prediction in first-episode psychosis.
在一项针对首发精神病的初步123I-IBZM单光子发射计算机断层扫描（SPECT）研究中，提示纹状体多巴胺能D2受体（D2R）结合与病前适应之间存在关联。本研究（n = 18）重复了这些结果，并且诊断时的D2R结合通过2年随访预测了精神分裂症结局的高概率。本研究结果为精神分裂症中D2R结合异常的证据提供了补充，并表明SPECT可能有助于首发精神病的结局预测。
