Davidson S R, Hoffman-Goetz L
Department of Health Studies and Gerontology, Faculty of Applied Health Studies, University of Waterloo, Waterloo, Ont., Canada N2L 3G1.
Brain Behav Immun. 2006 Mar;20(2):139-43. doi: 10.1016/j.bbi.2005.07.002. Epub 2005 Aug 22.
Aerobic exercise increases oxidant stress and leads to apoptosis of mouse intestinal lymphocytes (IL). The purpose of this study was to determine whether freewheel running prevents IL loss 24 h after a bout of strenuous exercise. Mice were randomly assigned to in-cage running wheels with 24 h access (WR) or individual cages without running wheels (NR) for 4 months. WR mice accumulated 364 km over 4 months and had higher cytochrome oxidase activity in the plantaris (p < .05), indicative of training. Total intestinal, CD3alphabeta, CD3gammadelta, CD8alpha, and CD8beta lymphocytes and intracellular glutathione were significantly lower in WR and NR mice 24 h post-exercise. The number of CD4 IL decreased 24 h after exercise in NR (p < .01) but not in WR mice relative to their respective no exercise controls. Thus, freewheel running in mice for 4 months prevented CD4 IL loss after acute exercise.
有氧运动增加氧化应激并导致小鼠肠道淋巴细胞（IL）凋亡。本研究的目的是确定自由轮跑步是否能防止剧烈运动后24小时IL的损失。将小鼠随机分为可24小时使用笼内跑步轮的组（WR）或无跑步轮的单独笼子组（NR），持续4个月。WR组小鼠在4个月内累计跑了364公里，其跖肌中的细胞色素氧化酶活性更高（p < 0.05），表明训练有效。运动后24小时，WR组和NR组小鼠的肠道总淋巴细胞、CD3αβ、CD3γδ、CD8α和CD8β淋巴细胞以及细胞内谷胱甘肽水平均显著降低。相对于各自的非运动对照组，NR组运动后24小时CD4 IL数量减少（p < 0.01），而WR组小鼠未减少。因此，小鼠4个月的自由轮跑步可防止急性运动后CD4 IL的损失。
