Kebede D, Alem A, Shibre T, Negash A, Deyassa N, Beyero T, Medhin G
Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia.
Schizophr Res. 2005 Oct 15;78(2-3):171-85. doi: 10.1016/j.schres.2005.05.028.
Prospective outcome studies based on a community sample of mostly neuroleptic naive cases of schizophrenia are uncommon.
To describe short-term symptomatic and functional outcomes of schizophrenia, and potential predictors of outcome.
After a baseline assessment, 63 incident and 208 prevalent cases of schizophrenia were followed by a yearly clinical assessment for an average of 2.5 (range 1-4) years. Scores of negative symptoms and positive symptoms were used as indicators of symptomatic outcomes. SF-36 scores of physical and social functioning, and role limitation due to mental health problems were used as indicators of functional outcomes. Several variables were evaluated as potential predictors of outcome in random coefficient models.
Functioning and other measures of health related quality of life were significantly diminished in cases as compared to the general population of the area at baseline and follow up. Of the socio-demographic and clinical factors evaluated, only lower negative and positive symptom scores were significantly associated with improvements in functioning. The level of functioning observed in cases from Butajira was lower than that reported for cases from developed countries.
Our findings are not in accord with other outcome studies that have reported better functional outcome for cases of schizophrenia from developing countries.
基于社区样本开展的前瞻性结局研究并不常见，这些样本大多为未使用过抗精神病药物的精神分裂症患者。
描述精神分裂症的短期症状及功能结局，以及结局的潜在预测因素。
在进行基线评估后，对63例新发病例和208例现患病例的精神分裂症患者进行了为期平均2.5年（范围1 - 4年）的年度临床评估。阴性症状和阳性症状评分用作症状结局指标。SF - 36身体和社会功能评分以及因心理健康问题导致的角色受限用作功能结局指标。在随机系数模型中评估了几个变量作为结局的潜在预测因素。
与该地区基线和随访时的一般人群相比，患者的功能及其他与健康相关的生活质量指标显著降低。在评估的社会人口学和临床因素中，只有较低的阴性和阳性症状评分与功能改善显著相关。布塔吉拉患者的功能水平低于发达国家报道的患者。
我们的研究结果与其他结局研究不一致，其他研究报告称发展中国家精神分裂症患者的功能结局更好。
