哮喘和慢性阻塞性肺疾病中支气管高反应性的机制

Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease.

作者信息

Grootendorst Diana C, Rabe Klaus F

机构信息

Leiden University Medical Centre, Department of Pulmonology C3-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

出版信息

Proc Am Thorac Soc. 2004;1(2):77-87. doi: 10.1513/pats.2306025.

DOI:10.1513/pats.2306025

PMID:16113417

Abstract

Bronchial hyperreactivity has long been recognized as a hallmark of chronic asthma. Less is known about the prevalence and mechanisms of hyperreactivity in chronic obstructive pulmonary disease (COPD). Currently, it is unclear whether the role and mechanisms of hyperreactivity are similar in patients with asthma and COPD or whether the underlying pathophysiologic abnormalities are different for both diseases. The aim of this review is to present an overview of current knowledge of the mechanisms of bronchial hyperreactivity in asthma and COPD.

摘要

支气管高反应性长期以来一直被认为是慢性哮喘的一个标志。关于慢性阻塞性肺疾病（COPD）中高反应性的患病率和机制，人们了解得较少。目前尚不清楚高反应性在哮喘和COPD患者中的作用和机制是否相似，或者这两种疾病潜在的病理生理异常是否不同。本综述的目的是概述目前关于哮喘和COPD中支气管高反应性机制的知识。