通过铜（I）催化的原子转移自由基聚合和叠氮化物-炔烃环加成反应制备病毒-糖聚合物缀合物。
Virus-glycopolymer conjugates by copper(I) catalysis of atom transfer radical polymerization and azide-alkyne cycloaddition.
作者信息
Sen Gupta Sayam, Raja Krishnaswami S, Kaltgrad Eiton, Strable Erica, Finn M G
机构信息
Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, USA.
出版信息
Chem Commun (Camb). 2005 Sep 14(34):4315-7. doi: 10.1039/b502444g. Epub 2005 Jul 19.
DOI:10.1039/b502444g
PMID:16113733
Abstract
The Cu(I)-catalyzed ATRP and azide-alkyne cycloaddition reactions together provide a versatile method for the synthesis of end-functionalized glycopolymers and their attachment to a suitably modified viral protein scaffold.
摘要
铜（I）催化的原子转移自由基聚合（ATRP）反应和叠氮化物-炔烃环加成反应共同提供了一种通用方法，用于合成末端官能化的糖聚合物，并将其连接到经过适当修饰的病毒蛋白支架上。
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