Pfaffenberger Stefan, Devcic-Kuhar Branka, Kastl Stefan P, Huber Kurt, Maurer Gerald, Wojta Johann, Gottsauner-Wolf Michael
Department of Internal Medicine II, University of Vienna, Austria.
Thromb Haemost. 2005 Jul;94(1):26-36. doi: 10.1160/TH04-12-0818.
Cardiovascular diseases are a major cause of mortality in the developed world. Efficacy of thrombolysis plays an important role in the management of acute myocardial infarction and cerebral insult both in the acute event and in the long-term outcome of these patients. New adjunctive strategies have been tested, therefore, to make thrombolytic therapies more effective and safer. Ultrasound Thrombolysis is a technique which showed promising results under in vitro conditions and in animal studies. Now clinical trials have to prove if it is also feasible for clinical application. This report gives an overview on different technical approaches and their current performances in the clinical setting. All original articles are chronologically ordered in tables providing detailed information on each study concerning experimental design, acoustical parameters and thrombolysis outcome.
心血管疾病是发达国家主要的死亡原因。溶栓疗效在急性心肌梗死和脑损伤的治疗中,对急性事件及这些患者的长期预后均起着重要作用。因此,人们已经测试了新的辅助策略,以使溶栓治疗更有效、更安全。超声溶栓是一种在体外条件和动物研究中显示出有前景结果的技术。现在临床试验必须证明其在临床应用中是否可行。本报告概述了不同的技术方法及其在临床环境中的当前表现。所有原始文章按时间顺序列于表格中,提供了有关每项研究的详细信息,包括实验设计、声学参数和溶栓结果。