侵袭性垂体腺瘤中垂体肿瘤转化基因、内皮抑素和碱性成纤维细胞生长因子mRNA的表达
[Expression of pituitary tumor transforming gene, endostatin, and basic fibroblast growth factor mRNAs in invasive pituitary adenomas].
作者信息
Chen Ling, Liu Yun-sheng, Wang Lu-shen, Yin Hai-gui, Hou Qing-tian, Liu Zhi-xiong, Chen Li-hua, Ling Feng
机构信息
Department of Neurosurgery, Xuanwu Hoaspital, Capital University of Medical Sciences, Beijing 100053.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Dec;29(6):651-3, 666.
OBJECTIVE
To investigate the effect of the expression of pituitary tumor transforming gene (PTTG), endostatin and basic fibroblast growth factor (bFGF) in invasive pituitary adenomas.
METHODS
Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of PTTG, endostatin, and bFGF mRNA in invasive and non-invasive pituitary adenomas.
RESULTS
The expression of PTTG and bFGF significantly increased in the invasive pituitary adenomas (all P < 0.01) compared with those in the non-invasive pituitary adenomas. However, the expression of endostatin significantly decreased in the invasive pituitary adenomas compared with the non-invasive pituitary adenomas (P < 0.01).
CONCLUSION
Increased expression of human PTTG and bFGF, and decreased expression of endostatin may be related to the genesis of tumor invasiveness. The feasible mechanism may be related to that the increased expression of PTTG plays a role in pituitary tumor invasiveness by altering the balance of tumor angiogenesis.
目的
探讨垂体肿瘤转化基因（PTTG）、内皮抑素和碱性成纤维细胞生长因子（bFGF）在侵袭性垂体腺瘤中的表达情况及其作用。
方法
采用逆转录-聚合酶链反应（RT-PCR）检测侵袭性和非侵袭性垂体腺瘤中PTTG、内皮抑素和bFGF mRNA的表达。
结果
与非侵袭性垂体腺瘤相比，侵袭性垂体腺瘤中PTTG和bFGF的表达显著增加（均P < 0.01）。然而，与非侵袭性垂体腺瘤相比，侵袭性垂体腺瘤中内皮抑素的表达显著降低（P < 0.01）。
结论
人PTTG和bFGF表达增加以及内皮抑素表达降低可能与肿瘤侵袭性的发生有关。其可能的机制可能与PTTG表达增加通过改变肿瘤血管生成平衡在垂体肿瘤侵袭性中发挥作用有关。
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