Araujo D M, Cotman C W
Department of Psychobiology, University of California, Irvine 92717.
Brain Res. 1992 Jan 8;569(1):141-5. doi: 10.1016/0006-8993(92)90380-r.
The effects of a synthetic homolog of beta-amyloid (beta 1-42) on the secretion of interleukin-1 (IL-1) and basic fibroblast growth factor (bFGF) from cultures of microglia and astrocytes, cells that surround beta-amyloid-containing plaques in Alzheimer's disease, were examined. Our results show that beta-amyloid not only enhances glial cell secretion of these factors, it stimulates the proliferation and morphological transformation of microglia. Since IL-1 and bFGF are known to elevate the synthesis of the beta-amyloid precursor protein and other plaque components, it is suggested that in this way, cascades may arise that contribute to the process of plaque development.
研究了β-淀粉样蛋白（β1-42）的一种合成同系物对小胶质细胞和星形胶质细胞培养物中白细胞介素-1（IL-1）和碱性成纤维细胞生长因子（bFGF）分泌的影响，这些细胞围绕着阿尔茨海默病中含β-淀粉样蛋白的斑块。我们的结果表明，β-淀粉样蛋白不仅增强了这些因子的胶质细胞分泌，还刺激了小胶质细胞的增殖和形态转化。由于已知IL-1和bFGF会提高β-淀粉样前体蛋白和其他斑块成分的合成，因此有人提出，可能会由此引发一系列级联反应，从而促进斑块形成过程。
