Rosiñol Laura, Carrió Ana, Bladé Joan, Queralt Rosa, Aymerich Marta, Cibeira Ma Teresa, Esteve Jordi, Rozman Maria, Campo Elías, Montserrat Emili
Haematology Department, Institute of Haematology and Oncology, Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Br J Haematol. 2005 Sep;130(5):729-32. doi: 10.1111/j.1365-2141.2005.05673.x.
Two variants of smoldering multiple myeloma (SMM) have been recognised: (i) an evolving type, characterised by a progressive increase in the M-protein size and short time to progression to overt multiple myeloma (MM) and (ii) a non-evolving type, with a long-lasting, stable M-protein and longer time to progression. Comparative genomic hybridisation (CGH) analyses in both subtypes of SMM (seven evolving and eight non-evolving SMM) were performed. Evolving SMM showed cytogenetic changes consistent with those found in de novo symptomatic MM (1q gains, chromosome 13 deletions) while the non-evolving variant showed no 1q gains and deletions were uncommon.
冒烟型多发性骨髓瘤（SMM）已被识别出两种变体：（i）进展型，其特征为M蛋白大小逐渐增加且进展为明显多发性骨髓瘤（MM）的时间较短；（ii）非进展型，具有持久、稳定的M蛋白且进展时间较长。对SMM的两种亚型（7例进展型和8例非进展型SMM）进行了比较基因组杂交（CGH）分析。进展型SMM显示出与初发有症状MM中发现的细胞遗传学变化一致（1q增益、13号染色体缺失），而非进展型变体未显示1q增益且缺失并不常见。
