Yokoyama H, Mori N, Osonoe K, Ishida S, Kumashiro H
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Brain Res. 1992 Feb 14;572(1-2):273-5. doi: 10.1016/0006-8993(92)90483-p.
Amygdaloid-kindled rats received intravenous human copper-zinc superoxide dismutase (CuZn-SOD) either in free form or entrapped within liposomes (SOD-L), at 5, 10 or 20 mg/kg. The animals were stimulated at the generalized seizure-triggering threshold 5 min, 2 h and then every 24 h after the drug was given, until 5 consecutive stage 5 seizures were induced. Free CuZn-SOD had little or no effect. However, SOD-L, particularly at 10 mg/kg, had a prolonged anticonvulsant effect, although there was great individual variation in the onset and duration of seizure suppression. This effect of SOD-L may be due to the ability of liposomes to act as a depot for the sustained release of drugs.
杏仁核点燃大鼠静脉注射游离形式或包裹于脂质体中的人铜锌超氧化物歧化酶（CuZn-SOD），剂量为5、10或20mg/kg。给药后5分钟、2小时，然后每24小时在全身癫痫发作触发阈值水平刺激动物，直至诱发连续5次5期癫痫发作。游离CuZn-SOD几乎没有作用。然而，脂质体包裹的超氧化物歧化酶（SOD-L），尤其是10mg/kg剂量时，具有延长的抗惊厥作用，尽管在癫痫发作抑制的起效时间和持续时间上存在很大的个体差异。SOD-L的这种作用可能是由于脂质体作为药物缓释储存库的能力。
