退化外周神经中睫状神经营养因子的合成减少。
Decreased synthesis of ciliary neurotrophic factor in degenerating peripheral nerves.
作者信息
Seniuk N, Altares M, Dunn R, Richardson P M
机构信息
Division of Neurosurgery, McGill University, Montreal, Canada.
出版信息
Brain Res. 1992 Feb 14;572(1-2):300-2. doi: 10.1016/0006-8993(92)90489-v.
The mRNA for ciliary neurotrophic factor in normal and injured sciatic nerves has been assayed by an RNase protection assay. The endoneurial concentration of ciliary neurotrophic factor mRNA is diminished in the distal nerve stump within three days of sciatic nerve transection, is less than one tenth of normal after one week, and remains low if regeneration does not occur. The synthesis of ciliary neurotrophic factor in injured peripheral nerves is decreased when and where the synthesis of nerve growth factor is increased.
采用核糖核酸酶保护分析法检测了正常和损伤坐骨神经中睫状神经营养因子的信使核糖核酸。坐骨神经横断后三天内，远侧神经断端中神经内膜的睫状神经营养因子信使核糖核酸浓度降低，一周后不到正常水平的十分之一，若未发生再生则仍维持在低水平。在损伤的周围神经中，当神经生长因子的合成增加时，睫状神经营养因子的合成则减少。
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