夜间睡眠呼吸暂停/低通气与载脂蛋白E ε4携带者的记忆表现较差有关。
Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers.
作者信息
O'Hara R, Schröder C M, Kraemer H C, Kryla N, Cao C, Miller E, Schatzberg A F, Yesavage J A, Murphy G M
机构信息
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5550, USA.
出版信息
Neurology. 2005 Aug 23;65(4):642-4. doi: 10.1212/01.wnl.0000173055.75950.bf.
The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.
作者调查了36名老年人、18名载脂蛋白E4（APOE ε4）携带者和18名非携带者中阻塞性睡眠呼吸暂停/低通气（OSAH）与认知之间的关系。仅在ε4携带者中，较多的呼吸事件对记忆功能产生了负面影响。这是第一项为APOE ε4与OSAH对老年人记忆产生负面相互作用提供初步证据的研究，这可能对治疗认知衰退和延缓痴呆症发病具有重要意义。
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