Swan Gary E, Lessov-Schlaggar Christina N, Carmelli Dorit, Schellenberg Gerard D, La Rue Asenath
Center for Health Sciences, SRI International, Menlo Park, California 94025, USA.
J Geriatr Psychiatry Neurol. 2005 Dec;18(4):196-201. doi: 10.1177/0891988705281864.
The relationship between apolipoprotein E (APOE) epsilon4 and change in cognition was examined in older men (n = 247; age = 75.0 +/- 3.5 years) and women (n = 79; age = 70.8 +/- 4.9 years) free of history of stroke. Participants were examined again 4.0 +/- 0.5 years later. Exclusion criteria were (1) initial scores on the Mini-Mental State Examination of 23 or less or (2) the presence of the APOE 2/4 genotype. Men with epsilon4 showed greater decline in some measures of executive function and verbal memory compared to those without epsilon4; women with epsilon4 showed greater decline in Trail Making test performance relative to women without the allele. A significant gender x APOE epsilon4 interaction was seen for change in performance on short delay cued recall. These results suggest that APOE epsilon4 is associated with cognitive decline differently in older adult men and women.
在无中风病史的老年男性（n = 247；年龄 = 75.0 ± 3.5岁）和女性（n = 79；年龄 = 70.8 ± 4.9岁）中，研究了载脂蛋白E（APOE）ε4与认知变化之间的关系。4.0 ± 0.5年后对参与者再次进行检查。排除标准为：（1）简易精神状态检查表初始得分≤23分；或（2）存在APOE 2/4基因型。与无ε4的男性相比，有ε4的男性在某些执行功能和言语记忆测量指标上表现出更大程度的下降；与无该等位基因的女性相比，有ε4的女性在连线测验表现上下降更明显。在短延迟线索回忆的表现变化方面，观察到显著的性别×APOE ε4交互作用。这些结果表明，APOE ε4在老年男性和女性中与认知衰退的关联有所不同。
