Colwell C S, Khalsa S B, Block G D
Department of Biology, University of Virginia, Charlottesville 22901.
Chronobiol Int. 1992 Jun;9(3):163-79. doi: 10.3109/07420529209064528.
This review summarizes our current understanding of the signal transduction cascade by which light causes phase shifts of the circadian oscillators found in the eye of Bulla and Aplysia. The isolated retina of these marine mollusks contains a circadian oscillator, a photoreceptor, and a light transduction pathway sufficient for entrainment. This preparation offers unique advantages for the cellular analysis of entrainment and the generation of circadian oscillations. There is evidence that similar cellular mechanisms may underlie mammalian and molluscan circadian oscillations. Thus, the models developed to explain entrainment in the molluscan retina are likely to have utility in exploring the mammalian suprachiasmatic nucleus.
本综述总结了我们目前对光引起泡螺和海兔眼睛中昼夜节律振荡器相位变化的信号转导级联的理解。这些海洋软体动物的离体视网膜包含一个昼夜节律振荡器、一个光感受器和一条足以实现同步化的光转导途径。这种制备方法为同步化的细胞分析和昼夜节律振荡的产生提供了独特的优势。有证据表明，类似的细胞机制可能是哺乳动物和软体动物昼夜节律振荡的基础。因此，为解释软体动物视网膜中的同步化而建立的模型可能有助于探索哺乳动物的视交叉上核。
