Block G D, Geusz M, Khalsa S B, Michel S, Whitmore D
Department of Biology, University of Virginia, Charlottesville 22901, USA.
Prog Brain Res. 1996;111:93-102. doi: 10.1016/s0079-6123(08)60402-1.
The Bulla ocular pacemaker provides remarkable opportunities for cellular study of circadian pacemaker systems. The demonstration of circadian oscillations within individual neurons maintained in culture provides us with a first occasion to study the biophysical and biochemical properties of bona fide neuronal circadian pacemakers. The ocular clock is robust and shares formal similarity with other circadian systems. The development of molecular techniques that can be applied to single neurons should allow research on the Bulla retina to continue to progress towards a molecular analysis of circadian timekeeping.
眼泡生物钟起搏器为昼夜节律起搏器系统的细胞研究提供了显著的机会。在培养的单个神经元中证明昼夜节律振荡，为我们首次研究真正的神经元昼夜节律起搏器的生物物理和生化特性提供了契机。眼内生物钟很稳定，并且与其他昼夜节律系统在形式上有相似之处。能够应用于单个神经元的分子技术的发展，应能使对眼泡视网膜的研究继续朝着昼夜节律计时的分子分析方向前进。
