Nixdorff U
European Prevention Center, München.
Biomed Tech (Berl). 2005 Jul-Aug;50(7-8):212-7. doi: 10.1515/BMT.2005.031.
Atherosclerosis is a systemic, over a long period silent, but at least in many cases severe illness with fatal events which in most Europeans represent the reason of death. The primary reduction of causative factors is very efficient, but, however, is not readily enough established within dominant curative treatment. In contrary, a cost effective risk modification is possible, especially by individualized risk stratification. The assessment of traditional risk factors (like lipid disorders, arterial hypertension) can not display the individual progression within the pathophysiologic continuum. Imaging modalities that examine morphology and function are able to assess preclinical data that represent validated surrogate parameters of the atherosclerotic process and in addition to traditional risk factors predictive informations. Predominantly, they allow the concept of primary and secondary preventive strategies.
动脉粥样硬化是一种全身性的、长期无症状但至少在许多情况下是严重的疾病,会引发致命事件,在大多数欧洲人中,它是死亡的原因。主要病因的减少非常有效,然而,在主流治疗中,这一做法尚未得到充分确立。相反,进行具有成本效益的风险修正却是可行的,尤其是通过个体化风险分层。对传统风险因素(如脂质紊乱、动脉高血压)的评估无法显示病理生理连续过程中的个体进展情况。检查形态和功能的成像方式能够评估代表动脉粥样硬化过程有效替代参数的临床前数据,以及除传统风险因素之外的预测信息。它们主要支持一级和二级预防策略的理念。