Schwenk Michael, Kluge Stefan, Jaroni Hanswerner
Landesgesundheitsamt, Wiederholdstr, 15, 70174 Stuttgart, Germany.
Toxicology. 2005 Oct 30;214(3):232-48. doi: 10.1016/j.tox.2005.06.016.
The threat of using chemical warfare agents still exists despite the 1993 Chemical Weapons Convention. Preparedness for attacks with chemical agents has become an important issue of national security programs. It can be anticipated that toxicologists will be increasingly involved in preparedness programs of their institutions and of the government, no matter whether they work in agencies, industry or universities. Toxicologists must get prepared to give fast and reliable advice in the case of an attack, a sabotage or an accident with release of toxic chemicals. They should be familiar with the principles of hazard management and with incident command structures and cooperate with first responders of other organizations involved such as fire department and medical emergency teams already in the planning phase. In the emergency planning phase, toxicologists are expected to help identifying possible hazards. Moreover, they consult public health services with regard to toxicosurveillance and advice hospitals regarding antidotes, decontamination procedures and shelters. They may be involved in the procurement of antidotes and of protective equipment and will support qualified analytical laboratories. In the response phase, toxicologists must be ready to gain and to interpret analytical data, to support the medical care of poisoned victims and to provide repeated risk assessment reports. This requires an on-scene access to databases and registries. The aftercare phase includes the identification of exposed persons, mapping of contaminated areas, organization of decontamination measures and the release of areas. A medical study may be initiated to observe long-term health effects. Good cooperation between regulatory and clinical toxicologists, specific education of toxicologist in the field of chemical emergencies and regular trainings are essential elements of good preparedness.
尽管有1993年的《化学武器公约》,但使用化学战剂的威胁依然存在。针对化学战剂袭击的防范已成为国家安全计划的一个重要问题。可以预见,毒理学家将越来越多地参与到其所在机构和政府的防范计划中,无论他们是在机构、行业还是大学工作。毒理学家必须做好准备,在发生袭击、破坏或有毒化学品泄漏事故时提供快速可靠的建议。他们应该熟悉危害管理原则和事故指挥结构,并在规划阶段就与其他相关组织的应急响应人员(如消防部门和医疗急救团队)合作。在应急规划阶段,毒理学家要协助识别可能的危害。此外,他们就毒物监测事宜向公共卫生服务机构提供咨询,并就解毒剂、去污程序和避难所事宜向医院提供建议。他们可能参与解毒剂和防护设备的采购,并支持合格的分析实验室。在应对阶段,毒理学家必须随时准备获取和解读分析数据,支持对中毒受害者的医疗救治,并提供反复的风险评估报告。这需要在现场能够访问数据库和登记处。善后阶段包括识别受暴露人员、绘制污染区域图、组织去污措施以及解除区域管制。可能会启动一项医学研究以观察长期健康影响。监管毒理学家和临床毒理学家之间的良好合作、毒理学家在化学紧急情况领域的专门培训以及定期演练是做好防范工作的关键要素。