Cambar J, Toussaint C, Lemoigne F
C R Seances Soc Biol Fil. 1979;173(5):898-903.
The present study originates in two experimental data: circadian variations evidence of water, electrolytes and solutes urinary excretion and theophylline diuretic and salidiuretic effects knowledge; we purpose to evidence theophylline-induced water and sodium renal excretion in rats as modified by the time of drug administration. Theophylline single dose is injected in 100 animals (20 lots of 5 rats) at 8 h, 14 h, 20 h or 2 h and urines are collected during a consecutive to injection hours long period: 8 h-14 h (I), 14 h-20 h (II), 20 h-2 h (III) or 2 h-8 h (IV). Diuresis increases in + 40,4 p. cent (I), in + 123,7 p. cent (II), in + 123,3 p. cent (III) in + 65,4 p. cent (IV). So, natriuresis increases in 39,6 p. cent (I), in 223,2 p. cent (II), in 114,3 p cent (III) and in 109,6 p. cent (IV). These results evidence that theophylline diuretic and natriuretic effects change strongly with injection time, being largest if it is injected at 14 h and slightest if injected at 8 h. Such observations prompt to study if the other pharmacological properties of theophylline, especially at pulmonary level, response also with a time-dependant intensity.
水、电解质和溶质尿排泄的昼夜变化证据以及茶碱的利尿和促钠排泄作用的相关知识；我们旨在证明药物给药时间对大鼠茶碱诱导的水和钠肾排泄的影响。将茶碱单剂量注射到100只动物（20组，每组5只大鼠）体内，注射时间分别为8时、14时、20时或2时，并在注射后的连续时间段内收集尿液：8时 - 14时（I）、14时 - 20时（II）、20时 - 2时（III）或2时 - 8时（IV）。利尿增加幅度在（I）组为 +40.4%，（II）组为 +123.7%，（III）组为 +123.3%，（IV）组为 +65.4%。因此，利钠增加幅度在（I）组为39.6%，（II）组为223.2%，（III）组为114.3%，（IV）组为109.6%。这些结果表明，茶碱的利尿和利钠作用随注射时间变化很大，在14时注射时作用最大，在8时注射时作用最小。这些观察结果促使我们研究茶碱的其他药理特性，尤其是在肺部水平，其反应强度是否也随时间变化。
