急性暴发性肝衰竭的肝移植

Liver transplantation for acute fulminant hepatic failure.

作者信息

Alsina A E, Hull D, Bartus S A, Schweizer R T

机构信息

Department of Surgery, Hartford Hospital, CT 06115.

出版信息

Conn Med. 1992 May;56(5):235-9.

PMID:1611894

Abstract

Orthotopic liver transplantation (OLT) remains the only option for progressive acute fulminant hepatic failure (FHF). The overall one-year survival is approximately 58% versus 75% for all patients undergoing OLT. Nevertheless, this is superior to the results obtained with medical management alone, which carries a mortality of approximately 60-85%. Seven of 32 patients at Hartford Hospital (22%) received liver transplants for acute FHF; the one-year survival was 57%. Four of seven patients are alive with complete neurologic recovery. One case is presented in detail.

摘要

原位肝移植（OLT）仍然是进行性急性暴发性肝衰竭（FHF）的唯一选择。接受OLT的所有患者的总体一年生存率约为58%，而所有患者的总体一年生存率为75%。然而，这优于单纯药物治疗的结果，单纯药物治疗的死亡率约为60%-85%。哈特福德医院32例患者中有7例（22%）因急性FHF接受了肝移植；一年生存率为57%。7例患者中有4例存活且神经功能完全恢复。详细介绍1例病例。