Moid Farah, Day Estella, Schneider Marta A, Goldstein Kenneth, DePalma Louis
Department of Pathology, George Washington University Hospital, Washington, DC 20037, USA.
Arch Pathol Lab Med. 2005 Sep;129(9):1164-7. doi: 10.5858/2005-129-1164-AICOTL.
We report a novel case of T-prolymphocytic leukemia, small cell variant, associated with complex cytogenetic findings including t(3;22)(q21;11.2) and elevated serum beta2-microglobulin. The diagnosis is based on morphologic, immunophenotypic, cytogenetic, and molecular analysis of peripheral blood and bone marrow. In contrast to most reported cases of T-prolymphocytic leukemia, this patient did not present with lymphadenopathy or organomegaly. Moreover, only a moderate leukocytosis (25.3 x 10(3)/microL) was evident at presentation. In the absence of any specific treatment, the patient is doing well, with a stable white blood cell count 12 months following presentation. Further investigation may be warranted to determine whether the unusual cytogenetic findings and elevated serum beta2-microglobulin are associated with the indolent clinical course in this patient.
我们报告了一例T-原淋巴细胞白血病小细胞变异型的新病例，该病例伴有复杂的细胞遗传学发现，包括t(3;22)(q21;11.2)以及血清β2-微球蛋白升高。诊断基于外周血和骨髓的形态学、免疫表型、细胞遗传学及分子分析。与大多数报道的T-原淋巴细胞白血病病例不同，该患者未出现淋巴结病或器官肿大。此外，就诊时仅表现为中度白细胞增多（25.3×10³/μL）。在未进行任何特异性治疗的情况下，患者状况良好，就诊12个月后白细胞计数稳定。可能需要进一步调查以确定这些异常的细胞遗传学发现和血清β2-微球蛋白升高是否与该患者的惰性临床病程相关。
