自发性II型糖尿病雄性CBA/Ca小鼠棕色和白色脂肪组织中对胰岛素生脂作用抗性的发展。

The development of resistance to the lipogenic effects of insulin in brown and white adipose tissue of spontaneously type II diabetic male CBA/Ca mice.

Mercer S W, Denton R M, Taberner P V

Department of Biochemistry, University of Bristol Medical School, U.K.

Int J Biochem. 1992 Jun;24(6):941-4. doi: 10.1016/0020-711x(92)90101-6.

Abstract

Lipogenesis in brown adipose tissue and white adipose tissue (WAT) was measured in vivo in spontaneously type II diabetic male CBA/Ca mice. 2. Lipogenic rates rose sharply in brown adipose tissue between the third and fourth month of life, concomitant with the onset of hyperinsulinaemia. However, lipogenic rates fell between the fourth and fifth month of age, and remained low, despite increasing circulating insulin concentrations. 3. Lipogenesis in white adipose tissue showed a modest response to hyperinsulinaemia followed by increasing resistance to elevated insulin concentrations after 5 months of age. 4. Studies involving either the injection of insulin or the intubation of glucose provided further evidence for the development of insulin resistance in both brown and white adipose tissue.

摘要

在自发性II型糖尿病雄性CBA/Ca小鼠体内测量了棕色脂肪组织和白色脂肪组织（WAT）中的脂肪生成。2. 在出生后第三个月到第四个月期间，棕色脂肪组织中的脂肪生成率急剧上升，这与高胰岛素血症的开始同时发生。然而，在第四个月到第五个月龄之间，脂肪生成率下降，并且尽管循环胰岛素浓度不断增加，但仍保持在低水平。3. 白色脂肪组织中的脂肪生成对高胰岛素血症有适度反应，随后在5个月龄后对升高的胰岛素浓度产生越来越大的抗性。4. 涉及注射胰岛素或插管给予葡萄糖的研究为棕色和白色脂肪组织中胰岛素抵抗的发展提供了进一步的证据。