Currò Giuseppe, Iapichino Giuliano, Melita Giuseppinella, Lorenzini Cesare, Cucinotta Eugenio
Department of Human Pathology, University of Messina, Messina, Italy.
JSLS. 2005 Jul-Sep;9(3):311-5.
This study aimed to determine whether laparoscopic cholecystectomy is a safe and advisable procedure in Child-Pugh C cirrhotic patients with symptomatic cholelithiasis.
The records of 42 laparoscopic cholecystectomies performed between January 1995 and February 2004 in patients with Child-Pugh A, B, and C cirrhosis were retrospectively reviewed, focusing on the 4 patients with Child-Pugh C cirrhosis.
Among the 38 Child-Pugh A and B patients, no deaths occurred. In this group, only 1 Child-Pugh B cirrhotic patient required blood transfusion, and postoperative morbidity occurred in 10 patients including hemorrhage, wound infection, intraabdominal collection, and cardiopulmonary complications (morbidity rate 26%). The mean postoperative stay was 5 days (range, 3 to 13). The indication for surgery in the 4 Child-Pugh C patients was acute cholecystitis. In this group, 2 deaths occurred for severe liver failure in 1 case and for sepsis in the other. One patient developed heavy gallbladder bed bleeding, and a second operation was necessary to control the hemorrhage. The morbidity rate was 75%. Only 1 patient had no complications. The mean postoperative stay was 10 days (range, 4 to 17).
Laparoscopic cholecystectomy is a safe procedure in well-selected Child-Pugh A and B cirrhotic patients indicated for surgery, but it is a very high-risk procedure in Child-Pugh C patients. Indications for surgery in Child-Pugh C patients should be evaluated very carefully and surgery should be avoided unless the patient needs an emergency cholecystectomy for acute cholecystitis. Child-Pugh C cirrhotic patients might better benefit from percutaneous drainage of the gallbladder.
本研究旨在确定腹腔镜胆囊切除术对于有症状胆结石的Child-Pugh C级肝硬化患者是否为安全且可取的手术。
回顾性分析1995年1月至2004年2月间对Child-Pugh A、B和C级肝硬化患者实施的42例腹腔镜胆囊切除术的记录,重点关注4例Child-Pugh C级肝硬化患者。
在38例Child-Pugh A级和B级患者中,无死亡病例。该组中,仅1例Child-Pugh B级肝硬化患者需要输血,10例患者发生术后并发症,包括出血、伤口感染、腹腔积液和心肺并发症(并发症发生率26%)。术后平均住院时间为5天(范围3至13天)。4例Child-Pugh C级患者的手术指征为急性胆囊炎。该组中,1例因严重肝衰竭死亡,另1例因脓毒症死亡。1例患者发生胆囊床大出血,需再次手术控制出血。并发症发生率为75%。仅1例患者无并发症。术后平均住院时间为10天(范围4至17天)。
腹腔镜胆囊切除术对于精心挑选的有手术指征的Child-Pugh A级和B级肝硬化患者是安全的手术,但对于Child-Pugh C级患者则是高风险手术。对于Child-Pugh C级患者的手术指征应非常谨慎地评估,除非患者因急性胆囊炎需要急诊胆囊切除术,否则应避免手术。Child-Pugh C级肝硬化患者可能从胆囊经皮引流中获益更多。