Zipori D
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
FASEB J. 1992 Jun;6(9):2691-7. doi: 10.1096/fasebj.6.9.1612293.
Blood-forming tissues are organized in well-defined microenvironments composed of hemopoietic cells and a supportive stroma of connective tissue and endothelium. Hemopoietic cells segregate to various lineages, all derived from a small population of pluripotent stem cells residing in the bone marrow. Regulation of growth and differentiation, particularly under conditions of perturbations, damage, and disease, is mediated by inducer colony-stimulating factors and interleukins counteracted by inhibitory cytokines. Whereas much is known about the mode of induction of differentiation, insufficient information is available to explain the process of stem cell renewal that is crucial for the longevity of the hemopoietic system. It is also only partially known how inhibition of hemopoietic processes occurs, and what molecules in blood-forming tissues signal organization into discrete patterns. This paper reviews recent progress that has opened new avenues to a better understanding of this highly complex issue.
造血组织被组织成明确的微环境，由造血细胞以及结缔组织和内皮细胞组成的支持性基质构成。造血细胞分化为各种谱系，所有这些谱系都源自骨髓中一小群多能干细胞。生长和分化的调节，特别是在扰动、损伤和疾病条件下，由诱导性集落刺激因子和白细胞介素介导，而抑制性细胞因子则起到抵消作用。虽然对分化诱导模式已有很多了解，但对于解释对造血系统寿命至关重要的干细胞更新过程的信息却不足。造血过程的抑制是如何发生的，以及造血组织中的哪些分子将组织信号传递成离散模式，也只是部分为人所知。本文综述了最近取得的进展，这些进展为更好地理解这个高度复杂的问题开辟了新途径。
