Bozdag S, Weyenberg W, Ludwig A
Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmaceutical Sciences, University of Antwerp, Belgium.
Pharmazie. 2005 Aug;60(8):593-7.
Various polymer mixtures were used to prepare gels: native drum dried waxy maize starch, Amioca starch, Carbopol 974P NF and powder mixtures obtained by cospray drying Amioca starch and Carbopol 974P NF, and by blending Carbopol 974P NF with Amioca starch or drum dried waxy maize starch. Oscillatory rheology was employed to investigate the influence of gamma-irradiation, but also of the different compositions (i.e. Carbopol 974P NF varied from 5 to 25% w/w in the powder mixtures tested) and the preparation procedures of the powder mixtures on the viscoelastic properties of the polymer dispersions. The rheological data showed that gamma-irradiation has a significant influence on the rheological behaviour of the polymers dispersed. More elastic properties were obtained when the concentration of Carbopol 974P NF was increased. The dispersions containing at least an amount of 15% Carbopol 974P NF (w/w) are mainly elastic. Contrary to cospray drying the powders, blending the powders leads to higher elastic and gel properties of the dispersed polymers.
天然滚筒干燥糯玉米淀粉、木薯淀粉、卡波姆974P NF以及通过共喷雾干燥木薯淀粉和卡波姆974P NF，以及将卡波姆974P NF与木薯淀粉或滚筒干燥糯玉米淀粉混合得到的粉末混合物。采用振荡流变学来研究γ辐射的影响，以及不同组成（即在所测试的粉末混合物中卡波姆974P NF的含量从5%到25% w/w不等）和粉末混合物的制备程序对聚合物分散体粘弹性性能的影响。流变学数据表明，γ辐射对分散的聚合物的流变行为有显著影响。当卡波姆974P NF的浓度增加时，可获得更多的弹性性能。含有至少15%卡波姆974P NF（w/w）的分散体主要具有弹性。与共喷雾干燥粉末相反，混合粉末会使分散的聚合物具有更高的弹性和凝胶性能。
