[EBV LMP2A在鼻咽癌组织中的表达及意义]
[Expression and significance of EBV LMP2A in nasopharyngeal cancer specimens].
作者信息
Xu Jiejie, Yao Kun, Yu Chenjie, Chen Xi, Li Baizhou, Sun Hua, Zhou Feng
机构信息
Department of Otolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Jun;19(11):484-7.
OBJECTIVE
To investigate the expression of Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A) in tumor tissues of nasopharyngeal cancer (NPC) and discuss the possibility (feasibility) that LMP2A was selected (to select
METHOD
The expression of EBV LMP2A was detected in the specimens of 40 patients with NPC and 38 cases with nasopharyngeal inflammation by S-P immunohistochemical methods.
RESULT
Of the 40 NPC specimens, 36 cases expressed LMP2A. There was no significant relationship between the expression of LMP2A and the histological differentiation of NPC. Thirty-three of the 38 cases with nasopharyngeal inflammation showed negative expression of LMP2A. There was a significant difference of LMP2A expression between NPC and nasopharyngeal inflammation.
CONCLUSION
The expression of EBV LMP2A is confirmed in the NPC specimens,and the negative results are seen in the majority of the inflammation cases. There is a possibility of applying LMP2A target antigen to induce specific immunoreaction to kill tumor cells of NPC.
目的
研究爱泼斯坦-巴尔病毒（EBV）潜伏膜蛋白2A（LMP2A）在鼻咽癌（NPC）肿瘤组织中的表达情况，并探讨LMP2A作为NPC免疫治疗靶抗原的可能性（可行性）。
方法
采用S-P免疫组化法检测40例NPC患者标本及38例鼻咽部炎症患者标本中EBV LMP2A的表达。
结果
40例NPC标本中，36例表达LMP2A。LMP2A表达与NPC的组织学分化无明显相关性。38例鼻咽部炎症患者中33例LMP2A表达阴性。NPC与鼻咽部炎症患者LMP2A表达存在显著差异。
结论
NPC标本中证实有EBV LMP2A表达，多数炎症病例呈阴性结果。应用LMP2A靶抗原有可能诱导特异性免疫反应以杀伤NPC肿瘤细胞。
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