Falkenberg U, Heuwieser W
FU Berlin, Tierklinik für Fortpflanzung.
Dtsch Tierarztl Wochenschr. 2005 Jul;112(7):252-6.
A field trial was conducted to elucidate the effect of the time of initiation of a repeated PGF2alpha-application in a 14 day interval for treatment of endometritis in dairy cows. On a commercial dairy farm in Brandenburg, Germany, a total of 494 dairy cows were examined by rectal palpation and adspection for signs of endometritis (vaginal discharge, enlarged uterus) between day 20 to 26 post partum (dpp). We performed two further examinations by rectal palpation and external adspection to monitor the puerperal phase (34.-40. dpp, 55.-61. dpp). All cows with symptoms of an endometritis were treated with PGF2alpha (0.15 mg R-Cloprostenol, Preloban, Intervet Deutschland GmbH Unterschleissheim) twice in a 14-day interval. In the group "Early" (n = 146) the first injection of Cloprostenol was administered at time of the 1st examination. In the group "Late" (n = 129) an identical treatment was administered in cows with endometritis, however it was started 14 days later (34.-40. dpp). The incidence of endometritis was 57.7% in the group "Early" and 53.5% in the group "Late" at the first time of examination. The 1st service conception rates for treated cows were 34% in the group "Early" vs. 37% in the group "Late". In the group "Early" differences were found in days open between treated cows with endometritis and untreated controls without symptoms of endometritis (99.1 d vs. 110.8 d, p > 0.05). In the group "Late", days open for treated (106.8 d) and untreated cows (108.0 d) were similar. The severity of endometritis influenced the percentage of cows pregnant at 200 dpp. Regarding cows with a severe endometritis (E2 and E3) the percentage of pregnant cows 200 dpp was higher in the group treated early (E2: 78.4%; E3: 80.0%) than in the group with the late initiation of the treatment (E2: 68.6%; E3: 54.5%, p < 0.05). Cows with a moderate endometritis (E1) had a similar percentage of pregnant cows (200 dpp) as the untreated cows without endometritis. It is concluded that application of PGF2alpha in the 4th and 6th week post partum in a 14 day interval in cases of severe endometritis is more effective than the application of the same treatment two weeks later.
进行了一项田间试验，以阐明每隔14天重复应用前列腺素F2α治疗奶牛子宫内膜炎的起始时间的影响。在德国勃兰登堡的一个商业奶牛场，在产后第20至26天（dpp）期间，通过直肠触诊和外部检查对总共494头奶牛进行了子宫内膜炎体征（阴道分泌物、子宫增大）检查。我们通过直肠触诊和外部检查进行了另外两次检查，以监测产褥期（34.-40. dpp，55.-61. dpp）。所有有子宫内膜炎症状的奶牛均每隔14天用前列腺素F2α（0.15毫克R-氯前列醇，Preloban，英特威德国有限公司 Unterschleissheim）治疗两次。在“早期”组（n = 146）中，第一次注射氯前列醇在第一次检查时进行。在“晚期”组（n = 129）中，对患有子宫内膜炎的奶牛进行相同的治疗，但在14天后开始（34.-40. dpp）。在第一次检查时，“早期”组子宫内膜炎的发病率为57.7%，“晚期”组为53.5%。治疗奶牛的首次配种受胎率在“早期”组为34%，而在“晚期”组为37%。在“早期”组中，患有子宫内膜炎的治疗奶牛与无子宫内膜炎症状的未治疗对照奶牛之间的空怀天数存在差异（99.1天对110.8天，p>0.05）。在“晚期”组中，治疗奶牛（106.8天）和未治疗奶牛（108.0天）的空怀天数相似。子宫内膜炎的严重程度影响了产后200天怀孕奶牛的百分比。对于患有严重子宫内膜炎（E2和E3）的奶牛，早期治疗组产后200天怀孕奶牛的百分比（E2：78.4%；E3：80.0%）高于治疗开始较晚的组（E2：68.6%；E3：54.5%，p<0.05）。患有中度子宫内膜炎（E1）的奶牛怀孕奶牛（产后200天）的百分比与无子宫内膜炎的未治疗奶牛相似。得出的结论是，对于严重子宫内膜炎病例，在产后第4周和第6周每隔14天应用前列腺素F2α比两周后应用相同治疗更有效。
