在黏液性卵巢癌中，细胞质HuR表达与上皮癌细胞相关，但与基质细胞环氧化酶-2表达无关。

Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma.

作者信息

Erkinheimo Tiina-Liisa, Sivula Anna, Lassus Heini, Heinonen Mira, Furneaux Henry, Haglund Caj, Butzow Ralf, Ristimäki Ari

机构信息

Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland.

出版信息

Gynecol Oncol. 2005 Oct;99(1):14-9. doi: 10.1016/j.ygyno.2005.04.047.

DOI:10.1016/j.ygyno.2005.04.047

PMID:16126263

Abstract

UNLABELLED

Cyclooxygenase-2 (COX-2) expression has been found to associate with poor prognosis in several types of carcinomas. HuR is an mRNA stability protein and it regulates the expression of COX-2.

OBJECTIVES AND METHODS

We analyzed the expression of COX-2 and HuR in 64 mucinous ovarian carcinoma specimens by immunohistochemistry.

RESULTS

In mucinous tumors, high COX-2 protein expression was found in epithelial cancer cells in 39% (22/56) and in stromal cells in 24% (13/55) of the specimens. The expression of COX-2 in cancer cells correlated with high grade (P = 0.0285), but stromal COX-2 expression had no correlation with any clinical parameter tested. Cytoplasmic HuR protein expression was observed in cancer cells in 47% (27/57) and in stromal cells in 7% (4/56) of the mucinous tumors, and it correlated with COX-2 expression in the cancer cells (P = 0.0162) but not in the stroma.

CONCLUSION

Our results support the hypothesis that cytoplasmic HuR is connected to COX-2 expression in ovarian carcinoma, but that its role is restricted to the transformed epithelial cancer cells.

摘要

未标记

已发现环氧合酶-2（COX-2）的表达与几种类型的癌症预后不良相关。HuR是一种mRNA稳定性蛋白，它调节COX-2的表达。

目的和方法

我们通过免疫组织化学分析了64例黏液性卵巢癌标本中COX-2和HuR的表达。

结果

在黏液性肿瘤中，39%（22/56）的标本上皮癌细胞和24%（13/55）的标本基质细胞中发现COX-2蛋白高表达。癌细胞中COX-2的表达与高级别相关（P = 0.0285），但基质COX-2表达与所检测的任何临床参数均无相关性。在47%（27/57）的黏液性肿瘤癌细胞和7%（4/56）的基质细胞中观察到细胞质HuR蛋白表达，并且它与癌细胞中COX-2的表达相关（P = 0.0162），但与基质中的COX-2表达无关。