Schumacher M, Doller P, Voigt K
Rofo. 1979 Sep;131(3):293-9. doi: 10.1055/s-0029-1231434.
In vivo and post mortem techniques for the radiological examination of normal brains have been developed, using 66 white adult rats. Aortic arch injections for survey angiograms (10 animals), selective catheterisation of the internal carotid artery (16 animals) and ventriculography by percutaneous needle puncture (20 animals) were performed in vivo; the animals survived and the examinations could be repeated. The techniques proved useful and accurate methods for the radiological demonstration of the topography and morphology of cerebral vessels and chambers; they also provided information on the function of the cerebral circulation and C.S.F. dynamics. The findings were checked and correlated by post mortem studies (20 animals) using contact radiography, micro-angiography and casts of the ventricles. As a result, extensive topographic and anatomic information concerning the cerebral vessels in the rat was obtained, including some microscopic-radiological findings. The combined use of these methods provided a basis for studying the growth of experimentally induced brain tumours and the effect of various types of treatment.
利用66只成年白色大鼠，已开发出用于正常大脑放射学检查的体内和死后技术。对10只动物进行主动脉弓注射以进行血管造影检查，对16只动物进行颈内动脉选择性插管，对20只动物进行经皮针刺脑室造影，这些均在活体动物上进行；动物存活，检查可重复进行。这些技术被证明是用于放射学显示脑血管和脑室的形态及结构的有用且准确的方法；它们还提供了有关脑循环功能和脑脊液动力学的信息。通过死后研究（20只动物），利用接触放射摄影、微血管造影和脑室铸型对这些发现进行了核对和关联。结果，获得了关于大鼠脑血管的广泛的形态和解剖学信息，包括一些微观放射学发现。这些方法的联合使用为研究实验性诱发脑肿瘤的生长以及各种治疗方法的效果提供了基础。
