Di Chiara Gaetano
Department of Toxicology, University of Cagliari, Italy.
Physiol Behav. 2005 Sep 15;86(1-2):9-10. doi: 10.1016/j.physbeh.2005.06.020.
Highly palatable food and drugs of abuse share the ability to stimulate dopamine transmission in the shell of the nucleus accumbens. However, while in the case of food this property is adaptively regulated in a negative fashion upon repeated exposure to the reward, no such regulation is operative towards drugs of abuse. Dysadaptive stimulation of dopamine transmission in the accumbens shell is assigned an important role in the compulsive motivation for drugs typical of drug addiction. It is speculated that disturbances of feeding behavior are related to loss of adaptive regulation of food-stimulated release of dopamine in the shell of the accumbens.
美味的食物和成瘾性药物都具有刺激伏隔核壳部多巴胺传递的能力。然而，就食物而言，这种特性在反复接触奖励后会以负向方式进行适应性调节，而成瘾性药物则不存在这种调节机制。伏隔核壳部多巴胺传递的适应不良性刺激在药物成瘾所特有的强迫性用药动机中被认为起着重要作用。据推测，进食行为的紊乱与伏隔核壳部食物刺激的多巴胺释放的适应性调节丧失有关。
