Fernández-Espejo E
Departamento de Fisiología Médica, Facultad de Medicina, Universidad de Sevilla, España.
Rev Neurol. 2000;30(9):845-9.
The nucleus accumbens is considered as the neural interface between motivation and action, playing a key role on feeding, sexual, reward, stress-related, drug self-administration behaviors, etc.
The nucleus accumbens possesses two territories, the core and shell, whose connectivity wiring gives a good picture of its motor and limbic aspects. The shell seems to behave as a 'coincidence detector', which can be activated during behavioral situations of adaptive value, thanks to its connections with prefrontal cortex, amygdala and hippocampus. The activation of the shell leads to the reinforcing of goal-directed motor sequences mediated by the core and prefrontal cortex, areas which are, linked to pyramidal and extrapyramidal motor systems. Dopamine secreted within the nucleus accumbens would acts as a 'neurostabilizer' of such processes.
The nucleus accumbens is made up of an 'electrophysiological coincidence detector' or shell serially connected to a 'motor sequencer' or core, both supporting the role of the nucleus accumbens as a limbic-motor interface.
伏隔核被认为是动机与行动之间的神经接口，在进食、性行为、奖赏、应激相关及药物自我给药行为等方面发挥关键作用。
伏隔核有两个区域，即核心区和壳区，其连接线路很好地展现了其运动和边缘系统方面的特点。壳区似乎起着“巧合探测器”的作用，由于其与前额叶皮质、杏仁核和海马体的连接，在具有适应性价值的行为情境中可被激活。壳区的激活会导致由核心区和前额叶皮质介导的目标导向运动序列得到强化，而这些区域与锥体和锥体外系运动系统相关联。伏隔核内分泌的多巴胺会充当此类过程的“神经稳定剂”。
伏隔核由一个“电生理巧合探测器”即壳区与一个“运动序列器”即核心区串联组成，二者均支持伏隔核作为边缘 - 运动接口的作用。
