Woolgar Julia Anne, Triantafyllou Asterios
Oral Pathology, Liverpool University Dental Hospital, Pembroke Place, Liverpool L3 5PS, UK.
Oral Oncol. 2005 Nov;41(10):1034-43. doi: 10.1016/j.oraloncology.2005.06.008. Epub 2005 Aug 29.
Standardised reporting of head and neck cancer resections according to guidelines issued by the UK Royal College of Pathologists was introduced as a routine procedure in 1998. The guidelines include definitions of "mucosal", "deep", "clear", "close" and "involved" surgical margins. This study of routine diagnostic material describes the frequency, type and morphological features of involved margins, and assesses the influence of tumour site and pathological T and N stage. 301 consecutive radical resection specimens for oral/oropharyngeal squamous cell carcinoma assessed according to the guidelines were appraised. 70 resections (23%) had involved margins. The frequency was related to primary tumour site, and pathological T and N stage. Mucosal involvement was evident in 11 resections, bone in 10, and deep soft tissue in 61-12 resections had multiple category involvement. Both anatomical factors and histological "markers" of tumour characteristics influence the status of surgical resection margins.
根据英国皇家病理学家学会发布的指南对头颈癌切除术进行标准化报告于1998年作为常规程序引入。这些指南包括“黏膜”“深部”“切缘阴性”“切缘接近”和“切缘阳性”手术切缘的定义。这项对常规诊断材料的研究描述了切缘阳性的频率、类型和形态学特征，并评估了肿瘤部位以及病理T和N分期的影响。根据这些指南对301例连续的口腔/口咽鳞状细胞癌根治性切除标本进行了评估。70例切除术（23%）切缘阳性。其频率与原发肿瘤部位、病理T和N分期有关。11例切除术中可见黏膜受累，10例有骨受累，61例有深部软组织受累，12例有多种类型受累。肿瘤特征的解剖学因素和组织学“标志物”均影响手术切缘状态。
