Hansen S R, Timmons S P, Dorman D C
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
J Am Vet Med Assoc. 1992 May 15;200(10):1512-4.
An overdose of up to 850 levothyroxine sodium tablets (0.2 mg) in a healthy 6-year-old 16.8-kg dog induced an episode of vomiting and hippus within 9 hours of ingestion. The dog was treated with activated charcoal and saline (magnesium sulfate) cathartic. Initially the serum concentration of thyroxine (T4) 4,900.9 nmol/L. On the second day, serum concentration of triiodothyronine (T3) was 5.3 nmol/L. Serum T4 concentration decreased slowly and was not determined to be normal until day 36. Serum T3 concentration was found to be normal on day 6. Serum alanine transaminase activity peaked on day 6 at 345 U/L. Significant abnormalities were not found during the following 36 days. Clinical signs of thyroid hormone toxicosis in dogs and cats include hyperactivity, lethargy, tachycardia, tachypnea, dyspnea, abnormal pupillary light reflexes, vomiting, and diarrhea. High overdoses of levothyroxine sodium in dogs should be managed by initial decontamination and administration of activated charcoal with a cathartic followed by supportive care.
一只健康的6岁、体重16.8千克的犬过量服用了多达850片左甲状腺素钠片（0.2毫克），在摄入后9小时内出现了呕吐和眼球震颤。该犬接受了活性炭和盐类（硫酸镁）泻药治疗。最初，血清甲状腺素（T4）浓度为4900.9纳摩尔/升。第二天，血清三碘甲状腺原氨酸（T3）浓度为5.3纳摩尔/升。血清T4浓度缓慢下降，直到第36天才恢复正常。血清T3浓度在第6天恢复正常。血清丙氨酸转氨酶活性在第6天达到峰值，为345 U/L。在接下来的36天内未发现明显异常。犬猫甲状腺激素中毒的临床症状包括多动、嗜睡、心动过速、呼吸急促、呼吸困难、异常瞳孔光反射、呕吐和腹泻。犬过量服用左甲状腺素钠应首先进行去污处理，给予活性炭和泻药，随后进行支持性护理。
