Sun Yao, Weber Karl T
Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Methods Mol Med. 2005;117:273-90. doi: 10.1385/1-59259-940-0:273.
A collagen network, composed largely of type I and III fibrillar collagens, is found in the heart's interstitial space. This network has multiple functions, including the preservation of tissue architecture and chamber geometry. Given its tensile strength, type I collagen is a major determinant of tissue stiffness. Its disproportionate accumulation, expressed in morphological terms as tissue fibrosis, increases myocardial passive and active stiffness and contributes to ventricular diastolic and systolic dysfunction. Various animal models of cardiac fibrosis have been used to study its functional consequences and to elucidate factors regulating the cellular and molecular biology of fibrogenesis. Herein, we present our experience and findings with several models of cardiac fibrosis.
一种主要由I型和III型纤维状胶原蛋白组成的胶原网络存在于心脏的间质空间中。该网络具有多种功能，包括维持组织结构和腔室几何形状。鉴于其抗张强度，I型胶原蛋白是组织硬度的主要决定因素。其不成比例的积累，在形态学上表现为组织纤维化，会增加心肌的被动和主动硬度，并导致心室舒张和收缩功能障碍。各种心脏纤维化动物模型已被用于研究其功能后果，并阐明调节纤维生成细胞和分子生物学的因素。在此，我们介绍我们在几种心脏纤维化模型中的经验和发现。
