Coleman L A, Naleway A L, Davis M E, Greenlee R T, Wilson D, McCarty D J
Marshfield Clinic Research Foundation, Epidemiology Research Center, Marshfield, WI, USA.
Lupus. 2005;14(7):526-8. doi: 10.1191/0961203305lu2152oa.
The fetal environment may be a contributing factor in the etiology of some adult diseases. This study examined whether birth weight, birth length and gestational age are associated with the subsequent development of systemic lupus erythematosus (SLE). The Marshfield Clinic Lupus Registry was searched to identify patients who were born at Saint Joseph's Hospital in Marshfield, Wisconsin, USA. Birth data on each case and five age-, sex-, and race-matched controls were recorded from medical and delivery room register records. Perinatal data were obtained for 23 cases and 115 controls. The unadjusted mean birth weight was similar for cases (3407 +/- 581 g) and controls (3422 +/- 514 g). Birth length was not different between groups. Birth weight adjusted for gestational age, analysed by conditional logistic regression, was not statistically significantly different between groups. We concluded that birth weight and length were similar among SLE cases and controls, suggesting that these perinatal characteristics are not associated with subsequent SLE.
胎儿环境可能是某些成人疾病病因的一个促成因素。本研究调查了出生体重、出生身长和胎龄是否与系统性红斑狼疮（SLE）的后续发病有关。检索了马什菲尔德诊所狼疮登记处，以确定在美国威斯康星州马什菲尔德圣约瑟夫医院出生的患者。从医疗和产房登记记录中记录了每个病例以及五个年龄、性别和种族匹配的对照的出生数据。获得了23例病例和115例对照的围产期数据。病例组（3407 +/- 581 g）和对照组（3422 +/- 514 g）的未调整平均出生体重相似。两组之间的出生身长没有差异。通过条件逻辑回归分析，调整胎龄后的出生体重在两组之间没有统计学上的显著差异。我们得出结论，SLE病例和对照之间的出生体重和身长相似，表明这些围产期特征与后续的SLE无关。
