Li Haibo, Zhou Changxin, Zhou Linfu, Chen Zhi, Yang Leixiang, Bai Hua, Wu Xiumei, Peng Hua, Zhao Yu
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Antivir Chem Chemother. 2005;16(4):277-82. doi: 10.1177/095632020501600407.
Three enantiomeric sesquiterpene lactones were isolated under the bioguidance of the suppression of hepatitis B virus (HBV) surface antigen (HBsAg) from Senecio species, a widely distributed Chinese medicinal herb traditionally used for the treatment of hepatitis B, dermatosis and inflammation. The anti-HBV activity of the purified compounds was measured; all of them showed suppressive activity on the expression of HBsAg and HBV e antigen (HBeAg) in the HepG2.2.15 cell line. Real-time quantitative PCR analysis showed that the studied compounds decreased the number of infectious virions released, but did not inhibit the intracellular HBV DNA. The results suggest that enantiomeric sesquiterpene lactones may possess the potential to work synergistically with other antiviral compounds for the treatment of HBV infection.
从千里光属植物中分离出三种对映体倍半萜内酯，该属植物是一种广泛分布的传统用于治疗乙型肝炎、皮肤病和炎症的中草药，其分离过程以抑制乙肝病毒（HBV）表面抗原（HBsAg）为生物导向。对纯化化合物的抗HBV活性进行了测定；所有化合物均对HepG2.2.15细胞系中HBsAg和乙肝病毒e抗原（HBeAg）的表达具有抑制活性。实时定量PCR分析表明，所研究的化合物减少了释放的感染性病毒粒子数量，但未抑制细胞内HBV DNA。结果表明，对映体倍半萜内酯可能具有与其他抗病毒化合物协同作用治疗HBV感染的潜力。
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