State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences, Kunming 650201, P.R.China.
Org Lett. 2014 Jan 17;16(2):370-3. doi: 10.1021/ol403198d. Epub 2013 Dec 20.
(±)-Sweriledugenin A, a pair of novel enantiomeric lactones, were isolated from Swertia leducii under the guidance of LC-MS investigation. The enantiomeric separation was achieved by HPLC on a chiral column. Their structures were determined by extensive NMR spectra, X-ray, and quantum calculations. (+)-Sweriledugenin A and (-)-sweriledugenin A showed activities inhibiting HBV DNA replication with the IC50 values of 36.86 and 26.55 μM on the HepG 2.2.15 cell line in vitro.
(±)-Sweriledugenin A 是一对新型的对映内酯，在 LC-MS 研究的指导下从川西獐牙菜中分离得到。对映异构体的分离是通过手性柱 HPLC 实现的。它们的结构通过广泛的 NMR 光谱、X 射线和量子计算确定。(+)-Sweriledugenin A 和 (-)-sweriledugenin A 在 HepG2.2.15 细胞系中体外对 HBV DNA 复制表现出抑制活性，其 IC50 值分别为 36.86 和 26.55 μM。
