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Why have neuro-protectants failed?: lessons learned from stroke trials.

作者信息

Muir K W, Teal Ph A

机构信息

University of Glasgow, Division of Clinical Neurosciences, Institute of Neurological Sciences Southern General Hospital, Glasgow G51 4TF, Scotland.

出版信息

J Neurol. 2005 Sep;252(9):1011-20. doi: 10.1007/s00415-005-0933-6. Epub 2005 Aug 25.

DOI:10.1007/s00415-005-0933-6

PMID:16133726

Abstract

摘要

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Why have neuro-protectants failed?: lessons learned from stroke trials.

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引用本文的文献

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本文引用的文献

The clomethiazole acute stroke study (CLASS): efficacy results in 545 patients classified as total anterior circulation syndrome (TACS).

J Stroke Cerebrovasc Dis. 1999 Jul-Aug;8(4):231-9. doi: 10.1016/s1052-3057(99)80072-x.

Cervene in acute ischemic stroke: results of a double-blind, placebo-controlled, dose-comparison study.

J Stroke Cerebrovasc Dis. 1999 Jul-Aug;8(4):224-30. doi: 10.1016/s1052-3057(99)80071-8.

Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials.

Lancet. 2004 Mar 6;363(9411):768-74. doi: 10.1016/S0140-6736(04)15692-4.

Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial.

Lancet. 2004 Feb 7;363(9407):439-45. doi: 10.1016/S0140-6736(04)15490-1.

Neuroprotective therapy for acute ischaemic stroke: down, but not out.

Lancet. 2004 Feb 7;363(9407):414-5. doi: 10.1016/S0140-6736(04)15522-0.

Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke.

Stroke. 2003 Nov;34(11):2543-8. doi: 10.1161/01.STR.0000092527.33910.89. Epub 2003 Oct 16.

Strengthening acute stroke trials through optimal use of disability end points.

Stroke. 2003 Nov;34(11):2676-80. doi: 10.1161/01.STR.0000096210.36741.E7. Epub 2003 Oct 16.

Management of acute stroke.

Lancet Neurol. 2002 May;1(1):41-50. doi: 10.1016/s1474-4422(02)00005-4.

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

Lancet Neurol. 2002 Oct;1(6):383-6. doi: 10.1016/s1474-4422(02)00164-3.

Design of future acute-stroke treatment trials.

Lancet Neurol. 2003 Jan;2(1):54-61. doi: 10.1016/s1474-4422(03)00267-9.

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Why have neuro-protectants failed?: lessons learned from stroke trials.

J Neurol. 2005 Sep;252(9):1011-20. doi: 10.1007/s00415-005-0933-6. Epub 2005 Aug 25.

Reasons why stroke trials underestimate the neuroprotective effects of drugs.

Stroke. 2002 Jan;33(1):324-5.

Neuroprotection failure in stroke.

Lancet. 2000 Sep 16;356(9234):1032-3. doi: 10.1016/S0140-6736(05)72654-4.

Wisdom and determination in the ongoing pursuit of the ever-elusive neuroprotective agent.

Stroke. 2011 Jun;42(6):1505-6. doi: 10.1161/STROKEAHA.111.617761. Epub 2011 May 5.

Stroke treatment--light at the end of the tunnel?

Nat Biotechnol. 2007 Aug;25(8):838-40. doi: 10.1038/nbt0807-838. Epub 2007 Aug 2.

Telemedicine, FAST-MAG and participation in clinical trials.

Int J Stroke. 2014 Feb;9(2):155. doi: 10.1111/ijs.12247.

Animal models of stroke: do they have value for discovering neuroprotective agents?

Trends Pharmacol Sci. 2003 Aug;24(8):402-8. doi: 10.1016/S0165-6147(03)00192-5.

Novel approaches to neuroprotection trials in acute ischemic stroke.

Stroke. 2013 Oct;44(10):2942-50. doi: 10.1161/STROKEAHA.113.000731. Epub 2013 Sep 10.

[Cerebral ischemia--challenges and perspectives].

Therapie. 2002 Nov-Dec;57(6):531-9.

Neuroprotection and stroke: time for a compromise.

J Neurochem. 2007 Nov;103(4):1302-9. doi: 10.1111/j.1471-4159.2007.04866.x. Epub 2007 Aug 28.

引用本文的文献

How to Pick a Neuroprotective Drug in Stroke Without Losing Your Mind?

Life (Basel). 2025 May 30;15(6):883. doi: 10.3390/life15060883.

Cell Therapy in Stroke-Cautious Steps Towards a Clinical Treatment.

Transl Stroke Res. 2018 Aug;9(4):321-332. doi: 10.1007/s12975-017-0587-6. Epub 2017 Nov 17.

Ischemic Preconditioning: The Long-Awaited Savior of Neuroprotection. Has It Arrived?

Neurotherapeutics. 2015 Jul;12(3):655-6. doi: 10.1007/s13311-015-0365-7.

Magnesium: potential roles in neurovascular disease.

Front Neurol. 2014 Apr 15;5:52. doi: 10.3389/fneur.2014.00052. eCollection 2014.

The 2012 Feinberg Lecture: treatment swift and treatment sure.

Stroke. 2013 Jan;44(1):270-7. doi: 10.1161/STROKEAHA.112.671354. Epub 2012 Dec 13.

Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model.

Brain Res. 2009 Jan 9;1247:196-211. doi: 10.1016/j.brainres.2008.10.015. Epub 2008 Nov 1.

Albumin therapy in acute stroke patients.

J Neurol. 2007 Jul;254(7):870-8. doi: 10.1007/s00415-006-0456-9. Epub 2007 Apr 13.

本文引用的文献

The clomethiazole acute stroke study (CLASS): efficacy results in 545 patients classified as total anterior circulation syndrome (TACS).

J Stroke Cerebrovasc Dis. 1999 Jul-Aug;8(4):231-9. doi: 10.1016/s1052-3057(99)80072-x.

Cervene in acute ischemic stroke: results of a double-blind, placebo-controlled, dose-comparison study.

J Stroke Cerebrovasc Dis. 1999 Jul-Aug;8(4):224-30. doi: 10.1016/s1052-3057(99)80071-8.

Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials.

Lancet. 2004 Mar 6;363(9411):768-74. doi: 10.1016/S0140-6736(04)15692-4.

Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial.

Lancet. 2004 Feb 7;363(9407):439-45. doi: 10.1016/S0140-6736(04)15490-1.

Neuroprotective therapy for acute ischaemic stroke: down, but not out.

Lancet. 2004 Feb 7;363(9407):414-5. doi: 10.1016/S0140-6736(04)15522-0.

Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke.

Stroke. 2003 Nov;34(11):2543-8. doi: 10.1161/01.STR.0000092527.33910.89. Epub 2003 Oct 16.

Strengthening acute stroke trials through optimal use of disability end points.

Stroke. 2003 Nov;34(11):2676-80. doi: 10.1161/01.STR.0000096210.36741.E7. Epub 2003 Oct 16.

Management of acute stroke.

Lancet Neurol. 2002 May;1(1):41-50. doi: 10.1016/s1474-4422(02)00005-4.

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

Lancet Neurol. 2002 Oct;1(6):383-6. doi: 10.1016/s1474-4422(02)00164-3.

Design of future acute-stroke treatment trials.

Lancet Neurol. 2003 Jan;2(1):54-61. doi: 10.1016/s1474-4422(03)00267-9.

Why have neuro-protectants failed?: lessons learned from stroke trials.

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