De Luca V, Voineskos D, Shinkai T, Wong G, Kennedy J L
Department of Psychiatry, Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont, Canada.
J Neural Transm (Vienna). 2005 Sep;112(9):1263-7. doi: 10.1007/s00702-005-0338-9.
Genome-scans performed in schizophrenia families have provided evidence for region 6p24-21 where variability may confer susceptibility to schizophrenia. Recent studies have implicated that gene DTNBP1 (dysbindin) in this region is strongly associated with schizophrenia. In a family based association study we investigated three markers located in the untranslated region of the DTNBP1 gene: rs909706, rs1047631 and rs742106. The sample size of our study is 117 families. No biased transmission towards the disorder was detected by haplotype analysis using TRANSMIT.
在精神分裂症家族中进行的全基因组扫描为6p24 - 21区域提供了证据，该区域的变异性可能使人易患精神分裂症。最近的研究表明，该区域的DTNBP1（dysbindin）基因与精神分裂症密切相关。在一项基于家族的关联研究中，我们调查了位于DTNBP1基因非翻译区的三个标记：rs909706、rs1047631和rs742106。我们的研究样本量为117个家族。使用TRANSMIT进行单倍型分析未检测到向该疾病的偏向性传递。
