Usherwood Edward J, Meadows Sarah K, Crist Sarah G, Bellfy Sarah C, Sentman Charles L
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA.
Eur J Immunol. 2005 Oct;35(10):2956-61. doi: 10.1002/eji.200526245.
Numerous studies have shown that NK cells are important in controlling the early stages of infection with alpha- or betaherpesviruses. In contrast, little is known about the impact of NK cells on gammaherpesvirus infections. We tested mice with defects in NK cells for their ability to resist murine gammaherpesvirus (MHV-68) infection. The depletion of NK cells had no effect on the control of the acute or latent stages of the infection. In addition, transgenic mice deficient in NK cells controlled the infection in a comparable manner to wild-type mice. We also showed that the antiviral CD8 T cell response was unaffected by the presence or absence NK cells. We conclude that NK cells contribute little to the control of MHV-68 infection, and therefore, NK cells are not essential for controlling all herpesvirus infections.
众多研究表明，自然杀伤（NK）细胞在控制α或β疱疹病毒感染的早期阶段起着重要作用。相比之下，关于NK细胞对γ疱疹病毒感染的影响却知之甚少。我们对NK细胞存在缺陷的小鼠抵抗鼠γ疱疹病毒（MHV - 68）感染的能力进行了测试。NK细胞的缺失对感染的急性期或潜伏期控制没有影响。此外，缺乏NK细胞的转基因小鼠对感染的控制方式与野生型小鼠相当。我们还表明，抗病毒CD8 T细胞反应不受NK细胞存在与否的影响。我们得出结论，NK细胞对MHV - 68感染的控制作用不大，因此，NK细胞并非控制所有疱疹病毒感染所必需。
