Stefanis Nicholas C, van Os Jim, Avramopoulos Dimitrios, Smyrnis Nikolaos, Evdokimidis Ioannis, Stefanis Costas N
Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 74 Vas. Sofias Ave., Athens 11528, Greece.
Am J Psychiatry. 2005 Sep;162(9):1752-4. doi: 10.1176/appi.ajp.162.9.1752.
It has been suggested that variation in catechol O-methyltransferase (COMT) activity associated with variation in COMT Val158Met genotypes may result in enhanced or reduced cognitive performance, depending on whether the phenotype requires cognitive stability or cognitive flexibility. The authors' goal was to determine whether, in confirmation of this prediction, performance on a measure of cognitive stability would be associated with Met loading.
COMT genotyping was investigated in relation to a measure of reaction time variability on the Continuous Performance Test, Identical Pairs Version, in a large and representative sample of 527 young men (mean age=21 years).
Met loading was associated with reduced reaction time variability.
Met genotype loading may confer enhanced "tuning" or greater stability in performance, possibly by stabilizing active neural representations in the prefrontal cortex during tasks involving working memory.
有人提出，儿茶酚-O-甲基转移酶（COMT）活性的变化与COMT Val158Met基因型的变化相关，这可能会导致认知表现增强或降低，具体取决于该表型需要认知稳定性还是认知灵活性。作者的目标是确定，为证实这一预测，认知稳定性测量的表现是否会与Met负荷相关。
在527名年轻男性（平均年龄 = 21岁）的大型代表性样本中，研究了COMT基因分型与连续性能测试（相同配对版本）中反应时间变异性测量之间的关系。
Met负荷与反应时间变异性降低相关。
Met基因型负荷可能通过在涉及工作记忆的任务中稳定前额叶皮层中的活跃神经表征，从而赋予增强的“调节”或更好的表现稳定性。
