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Coartem (artemether-lumefantrine) in Africa: the beginning of the end?

作者信息

Hastings Ian M, Ward Stephen A

出版信息

J Infect Dis. 2005 Oct 1;192(7):1303-4; author reply 1304-5. doi: 10.1086/432554.

DOI:10.1086/432554
PMID:16136476
Abstract
摘要

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Coartem (artemether-lumefantrine) in Africa: the beginning of the end?非洲的科泰复(蒿甲醚-本芴醇):终结的开始?
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2
In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem).蒿甲醚-本芴醇(复方蒿甲醚)对恶性疟原虫pfmdr1 86N编码等位基因的体内选择
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The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa.pfmdr1在非洲恶性疟原虫对蒿甲醚-本芴醇耐受性中的作用。
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Artemether-lumefantrine: an option for malaria.蒿甲醚-本芴醇:疟疾的一种选择。
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Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.耐多药恶性疟原虫疟疾对蒿甲醚-本芴醇治疗反应的分子和药理学决定因素
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Artemether-Lumefantrine Treatment Selects Plasmodium falciparum Multidrug Resistance 1 (pfmdr1) Increased Copy Number Among African Malaria Infections.蒿甲醚-本芴醇治疗在非洲疟疾感染中选择了恶性疟原虫多药耐药性1(pfmdr1)拷贝数增加的情况。
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Out of Africa: Increasing reports of artemether-lumefantrine treatment failures of uncomplicated Plasmodium falciparum infection.走出非洲:青蒿琥酯-本芴醇治疗非复杂性恶性疟原虫感染失败的报告日益增多。
J Travel Med. 2023 Dec 28;30(8). doi: 10.1093/jtm/taad159.
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Selection of K76 and N86 Coding Alleles after Uncomplicated Malaria Treatment by Artemether-Lumefantrine in Mali.
在马里使用青蒿琥酯-咯萘啶治疗无并发症疟疾后 K76 和 N86 编码等位基因的选择。
Int J Mol Sci. 2021 Jun 3;22(11):6057. doi: 10.3390/ijms22116057.
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Assessment of molecular markers of anti-malarial drug resistance among children participating in a therapeutic efficacy study in western Kenya.评估肯尼亚西部参加抗疟药物疗效研究的儿童中的抗疟药物耐药性分子标志物。
Malar J. 2020 Aug 14;19(1):291. doi: 10.1186/s12936-020-03358-7.
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Sustained Susceptibility of Plasmodium falciparum to Artemisinin Derivatives but Increasing Tolerance to Artemisinin Combination Therapy Partner Quinolines in The Gambia.冈比亚恶性疟原虫对青蒿素衍生物持续敏感,但对青蒿素联合疗法中的喹啉类药物耐受性增加。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.00759-17. Print 2017 Dec.
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Quantifying the pharmacology of antimalarial drug combination therapy.定量评估抗疟药物联合治疗的药理学。
Sci Rep. 2016 Sep 8;6:32762. doi: 10.1038/srep32762.
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Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria.大环内酯类药物及基于类似作用机制的相关抗生素,如用于疟疾治疗的林可酰胺类药物。
Malar J. 2016 Feb 12;15:85. doi: 10.1186/s12936-016-1114-z.
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Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea.巴布亚新几内亚两个地区与恶性疟原虫和间日疟原虫耐药性相关的突变流行率存在显著地理差异。
Malar J. 2015 Oct 9;14:399. doi: 10.1186/s12936-015-0879-9.
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Reply to "no robust evidence of lumefantrine resistance".对“无确凿证据表明存在甲氟喹耐药性”的回复。
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Antimicrob Agents Chemother. 2015 Oct;59(10):6419-27. doi: 10.1128/AAC.00482-15. Epub 2015 Aug 3.