[大豆异黄酮对去卵巢小鼠认知功能的影响]
[Effect of soybean isoflavone on the cognitive function in ovariectomized mice].
作者信息
Zhu Jian-Lin, Yang Gui-Lian, Huang Yi-Ming
机构信息
Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha 410078, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Feb;29(1):81-3.
OBJECTIVE
To explore the effect of soybean isoflavone on the cognitive function in ovariectomized mice and to study the cognitive function mechanism of soybean isoflavone.
METHODS
Forty-five Kunming female mice were randomly assigned into 5 groups: A (sham operated); B (ovariectomized, OVX); C (OVX + low dose soybean isoflavone); D (OVX + moderate dose soybean isoflavone); and E (OVX + high dose soybean isoflavone). The experiment lasted 60 days.
RESULTS
Ovariectomy significantly elongated the destination time of water maze, shortened the latent time of step-down test, decreased SOD of serum and Na+ K+ -ATPase and Ca2+ Mg2+ -ATPase of brain, and increased malonaldehyde of serum and monoamine oxidase of brain, which-could be inhibited by soybean isoflavone consumption.
CONCLUSION
The continuous oral administration of soybean isoflavone can improve the cognitive function of ovariectomized mice.
目的
探讨大豆异黄酮对去卵巢小鼠认知功能的影响，并研究大豆异黄酮的认知功能作用机制。
方法
将45只昆明雌性小鼠随机分为5组：A组（假手术组）；B组（去卵巢组，OVX）；C组（去卵巢+低剂量大豆异黄酮组）；D组（去卵巢+中剂量大豆异黄酮组）；E组（去卵巢+高剂量大豆异黄酮组）。实验持续60天。
结果
去卵巢显著延长了水迷宫的到达时间，缩短了跳台试验的潜伏期，降低了血清超氧化物歧化酶（SOD）以及脑内钠钾-ATP酶和钙镁-ATP酶的活性，增加了血清丙二醛和脑内单胺氧化酶的含量，而大豆异黄酮摄入可抑制这些变化。
结论
持续口服大豆异黄酮可改善去卵巢小鼠的认知功能。
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