Fathman C G
Department of Medicine, Stanford University School of Medicine, CA 94305-5111.
J Rheumatol Suppl. 1992 Jan;32:12-5; discussion 15-7.
By understanding normal immune response, it has been possible to develop therapeutic strategies toward the treatment of autoimmune disease. The association of autoimmune disease with the major histocompatibility complex (MHC) class II gene products suggests that the inductive events in which the putative autoantigen is presented on the surface of antigen presenting cells in the context of the MHC class II gene products and is recognized by CD4(+) helper or inducer T cells form an interesting target for immunotherapeutic intervention. By understanding the structure/function relationships of T cell receptors for antigen, it might be possible to develop novel immunotherapeutic strategies for the treatment of seropositive rheumatoid arthritis. Studies described below review recent progress in understanding the components of the ternary complex and suggest possible areas of immunotherapeutic intervention.
通过了解正常免疫反应，已能够开发出针对自身免疫性疾病治疗的策略。自身免疫性疾病与主要组织相容性复合体（MHC）II类基因产物的关联表明，在MHC II类基因产物的背景下，假定的自身抗原呈递在抗原呈递细胞表面并被CD4(+)辅助或诱导性T细胞识别的诱导事件，形成了免疫治疗干预的一个有趣靶点。通过了解抗原T细胞受体的结构/功能关系，有可能开发出治疗血清阳性类风湿性关节炎的新型免疫治疗策略。以下所述研究回顾了在理解三元复合物组成方面的最新进展，并提出了免疫治疗干预的可能领域。
