2型糖尿病中凝血因子V G1691A（莱顿突变）和凝血酶原G20210A单核苷酸多态性

Factor V G1691A (Leiden) and prothrombin G20210A single-nucleotide polymorphisms in type 2 diabetes mellitus.

作者信息

Wakim-Ghorayeb Saria F, Keleshian Sose H, Timson Georgina, Finan Ramzi R, Najm Pierre, Irani-Hakime Noha, Almawi Wassim Y

机构信息

St. Georges University Hospital, Beirut.

出版信息

Am J Hematol. 2005 Sep;80(1):84-6. doi: 10.1002/ajh.20406.

DOI:10.1002/ajh.20406

PMID:16138347

Abstract

The association of the single nucleotide polymorphisms (SNPs) G1691A in coagulation factor V (FV)-Leiden and G20210A in prothrombin (PRT) genes with type 2 diabetes mellitus (T2DM) were analyzed in 112 T2DM patients (58 males, 54 females; mean age 55.24 +/- 13.5 years) and 249 healthy control subjects (118 males, 131 females; mean age 53.03 +/- 13.8 years). No association was found for FV-Leiden with T2DM, as the frequency of the G/G (82.1% vs. 85.5%), G/A (17.0% vs. 14.1%), and A/A (0.9% vs. 0.4%) genotypes was not different between patients and controls, respectively (P = 0.644). Similarly, lack of association of PRT G20210A with T2DM was seen among the population studied, and the frequency of the G/G (92.9% vs. 97.2%), G/A (6.3% vs. 2.8%), and A/A (0.9% vs. 0.0%) genotypes was similar among patients and controls, respectively (P = 0.094). Neither FV-Leiden nor PRT G20210A was associated with, and no evidence for interactions between these mutations was seen in, T2DM.

摘要

在112例2型糖尿病（T2DM）患者（58例男性，54例女性；平均年龄55.24±13.5岁）和249例健康对照者（118例男性，131例女性；平均年龄53.03±13.8岁）中，分析了凝血因子V（FV）-Leiden基因中的单核苷酸多态性（SNP）G1691A和凝血酶原（PRT）基因中的G20210A与2型糖尿病（T2DM）的关联。未发现FV-Leiden与T2DM有关联，因为患者和对照中G/G（82.1%对85.5%）、G/A（17.0%对14.1%）和A/A（0.9%对0.4%）基因型的频率分别无差异（P = 0.644）。同样，在所研究的人群中也未发现PRT G20210A与T2DM有关联，患者和对照中G/G（92.9%对97.2%）、G/A（6.3%对2.8%）和A/A（0.9%对0.0%）基因型的频率分别相似（P = 0.094）。FV-Leiden和PRT G20210A均与T2DM无关联，且未发现这些突变之间存在相互作用的证据。