Katori M, Kawamura M, Sawada M
Dept. Pharmacology, Kitasato University, School of Medicine.
Nihon Rinsho. 1992 Feb;50(2):349-54.
Artifactual formation of thromboxane (TX) B2 during blood collection falsifies real value of TXB2 in plasma. A part (29.3%) of TXB2 is metabolized to 11-dehydro (DH)-TXB2 in several organs. 11-DH-TXB2 was not generated during blood collection or during serum formation. The peak amount of 11-DH-TXB2 after intravenous injection of TXB2 to rabbits was lower than that of TXB2, but the level of 11-DH-TXB2 was kept 2-3 times higher than that of TXB2 even after more than 5 min. A half life of 11-DH-TXB2 is 45-60 min in the human. Large species differences were found. In human urine, 11-DH-TXB2 was excreted 1.5-5.8 times more than 2,3-dinor-TXB2. Patients with ARDS and DIC, who received platelet transfusion, excreted increased amounts of 2,3-dinor-TXB2 and 11-DH-TXB2 in urine. 11-DH-TXB2 may be a useful parameter of TXA2 formation in pathological states.
血液采集过程中血栓素（TX）B2的人为形成会使血浆中TXB2的真实值出现偏差。TXB2的一部分（29.3%）在多个器官中代谢为11-脱氢（DH）-TXB2。在血液采集或血清形成过程中不会生成11-DH-TXB2。给兔子静脉注射TXB2后，11-DH-TXB2的峰值量低于TXB2，但即使在5分钟以上，11-DH-TXB2的水平仍比TXB2高2至3倍。11-DH-TXB2在人体内的半衰期为45至60分钟。发现存在较大的物种差异。在人类尿液中，11-DH-TXB2的排泄量比2,3-二去甲-TXB2多1.5至5.8倍。接受血小板输注的急性呼吸窘迫综合征（ARDS）和弥散性血管内凝血（DIC）患者尿液中2,3-二去甲-TXB2和11-DH-TXB2的排泄量增加。11-DH-TXB2可能是病理状态下TXA2形成的一个有用参数。
