Davies Susan, Kattel Roshani, Bhatia Bhairavi, Petherwick Adam, Chapman Tracey
Department of Biology, University College London, Darwin Building, Gower Street, London, UK.
Exp Gerontol. 2005 Oct;40(10):784-92. doi: 10.1016/j.exger.2005.07.009. Epub 2005 Sep 1.
Dietary Restriction (DR) extends lifespan in a range of model organisms such as yeast, flies and worms suggesting it is a 'public' mechanism for longevity extension. Lifespan extension has also been reported in the Mediterranean fruit fly (medfly), Ceratitis capitata in response to various types of dietary manipulation, however, the responses can be complex. There are also reported differences in the responses of medfly and Drosophila melanogaster longevity to DR, but it is not clear to what extent these are due to differences in feeding protocols or to what extent they reflect real biological differences. In order to investigate this, we applied a DR feeding protocol similar to that used in many D. melanogaster studies and tested for effects on male and female virgin and mated medfly longevity. Our results show a clear effect of DR and a cost of reproduction for both sexes. Female flies lived significantly longer than male flies at all food levels, indicating minimal interactions between diet and sex in determining longevity.
饮食限制（DR）可延长一系列模式生物的寿命，如酵母、果蝇和线虫，这表明它是一种延长寿命的“通用”机制。据报道，地中海实蝇（medfly），即蜡实蝇（Ceratitis capitata）在受到各种饮食操控时，寿命也会延长，然而，其反应可能很复杂。也有报道称，地中海实蝇和黑腹果蝇在对饮食限制的寿命反应上存在差异，但尚不清楚这些差异在多大程度上是由于喂食方案的不同，或者在多大程度上反映了真正的生物学差异。为了对此进行研究，我们采用了一种类似于许多黑腹果蝇研究中使用的饮食限制喂食方案，并测试其对未交配和已交配的雄性和雌性地中海实蝇寿命的影响。我们的结果显示了饮食限制的明显效果以及两性的繁殖成本。在所有食物水平下，雌性果蝇的寿命都显著长于雄性果蝇，这表明在决定寿命方面，饮食和性别之间的相互作用最小。
