从成血管细胞到造血干细胞：内皮细胞的联系？

From hemangioblast to hematopoietic stem cell: an endothelial connection?

作者信息

Jaffredo Thierry, Nottingham Wade, Liddiard Kate, Bollerot Karine, Pouget Claire, de Bruijn Marella

机构信息

Developmental Biology Laboratory, UPMC, Paris, France.

出版信息

Exp Hematol. 2005 Sep;33(9):1029-40. doi: 10.1016/j.exphem.2005.06.005.

DOI:10.1016/j.exphem.2005.06.005

PMID:16140151

Abstract

The developmental origin of hematopoietic stem cells has been the subject of much research. Now that the developmental link between the hematopoietic system and the vasculature has been well established, questions remain regarding the precise cellular origin of definitive hematopoietic cells and at what point they branch off from the endothelial lineage. Do they emerge directly from a hemangioblast-type cell, similar to what is proposed for primitive yolk sac hematopoiesis, or are they generated via an endothelial intermediate, the hemogenic endothelium? In this review, we will give an overview of the data obtained from the mouse and avian models on the cellular origins of the hematopoietic system.

摘要

造血干细胞的发育起源一直是众多研究的主题。既然造血系统与脉管系统之间的发育联系已得到充分确立，那么关于定型造血细胞的确切细胞起源以及它们从内皮细胞谱系分支出来的时间点，仍然存在问题。它们是直接从类似于原始卵黄囊造血所提出的成血管细胞类型的细胞中产生，还是通过内皮细胞中间体——造血内皮细胞产生？在这篇综述中，我们将概述从小鼠和禽类模型中获得的关于造血系统细胞起源的数据。